After taking the ADT treatment for 18 months, my father's PSA level started to increase since mid of 2014 (hormone refractory prostate cancer?). Changing the Lucrine to Zoladex did not help with the PSA. At the moment my father is still doing his activities normally and exercise regularly.
The doctor advised my father to try Zytiga, but due to high costs and unclear benefit of it looks like we will not do it. Can anyone share their experience and alternative treatment for the hormone refractory prostate cancer? Since hormone injection and Casodex are no longer effective, should we just stop it?
At the moment our preference is to continue the herbal treatment and maintain the current quality of life.
Below is the history of my father's treatment so far:
A patient in Bandung, Indonesia.
Age at diagnosis: 72 years.
Family History: No PCa in family, no cancer history.
Past surgeries: None.
Other health problem: None.
Diet: Vegan, since herbal treatment was started in Jan. '13.
17 Dec. '12: PSA of 518.28
20 Dec. '12: Did the PSA Test, DRE, MRI and Biopsy.
PSA level of 445.5. MRI conclusion states "Thoracolumbar spines: Thoracic and Lumbar Metastasis".
31 Dec. '12: Biopsy results: Gleason Score 4+4
7 Jan. '13: Took Lucrine 11.25 mg injection and start Casodex 50 mg daily for 2 weeks
8 Jan. '13: Start herbal treatment from Ca Care (www.cacare.com), start vegan diet.
9 Jan. '13: PSA of 455.43
9 Feb. '13: PSA of 21.29
9 Mar. '13: PSA of 8.18
9 Apr. '13: Took Lucrine 11.25 mg injection and Casodex 50 mg daily for 2 weeks
10 May '13: PSA of 1.26
10 Jun '13: PSA of 1.33
9 Jul. '13: Took Lucrine 11.25 mg injection and Casodex 50 mg daily for 2 weeks
9 Sep. '13: PSA of 1.28
1 Oct. '13: Took Lucrine 11.25 mg injection. Stopped Casodex based on the advise from the urologist.
20 Dec. '13: PSA of 2.38
22 Dec. '13: Took Lucrine 11.25 mg injection and start Casodex 50 mg daily for 1 month.
24 Jan. '14: PSA of 1.29
18 Mar. '14: PSA of 2.13
18 Mar. '14: Took Lucrine 11.25 mg injection and Casodex 50 mg daily for 1 month.
10 Jun. '14: PSA of 5.77
10 Jun. '14: Took Lucrine 11.25 mg injection and Casodex 50 mg daily for 3 months.
8 Sep. '14: PSA of 6.34
8 Sep. '14: Took Lucrine 11.25 mg injection and Casodex 50 mg daily for 3 months.
10 Oct. '14: PSA of 10.48
3 Dec. '14: Change to Zoladex injection and continue Casodex 50 mg daily for 3 months.
2 Mar. '15: PSA of 18.41
2 Mar. '15: Took Zoladex injection and Casodex 50 mg daily for 3 months.
1 Apr. '15: PSA of 27.55
1 Jun. '15: PSA of 49.06
1 Jun. '15: Took Zoladex injection and Casodex 50 mg daily for 3 months.
PSA on 2 Nov 15: 278
PSA on 2 Feb 16: 1,479
PSA on 26 Mar 16: 7,517
With the incredible increase in PSA level, my father's condition has also deteriorated and his legs are getting heavier to move. In addition to that the urinating frequency has also increased (he still insist not to use adult pampers 😁) and he lost the appetite to eat.
In May 16, the PSA raised to 15,000 and he had Bondronat injection and started Zytiga. He started to feel bone pain and will see the onco tomorrow to consult. He is still doing his day to day activities and we just ask him to do it carefully.
Thanks to Roy White in Australia for his advice, feedback and the brochures!
In mid May 16, my father started Zytiga as the PSA was extremely high.
After taking Zytiga, his PSA flared to 30,000 and my father had difficulties to move and woke up from bed, and felt bone pain. The oncologist gave morphine, however, it only helped for a while.
On the 25th of June afternoon my father was brought to hospital as the blood count was very low, and sadly on 26th Jun evening my father passed away.